منابع مشابه
Colloquium Complexity and robustness
Highly optimized tolerance (HOT) was recently introduced as a conceptual framework to study fundamental aspects of complexity. HOT is motivated primarily by systems from biology and engineering and emphasizes, (i) highly structured, nongeneric, self-dissimilar internal configurations, and (ii) robust yet fragile external behavior. HOT claims these are the most important features of complexity a...
متن کاملComplexity and robustness.
Highly optimized tolerance (HOT) was recently introduced as a conceptual framework to study fundamental aspects of complexity. HOT is motivated primarily by systems from biology and engineering and emphasizes, (i) highly structured, nongeneric, self-dissimilar internal configurations, and (ii) robust yet fragile external behavior. HOT claims these are the most important features of complexity a...
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As biologists delve deeper into genomics, gene regulation and subcellular interactions, the networks that regulate cell function can sometimes appear wildly and gratuitously elaborate, since it is known that enormous complexity is not necessary for basic cellular survival and function. Minimal cellular life is thought to require about ~300 genes, yet even E. coli have ~4000 genes. Gene knockout...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2002
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.012582499